Effect of Grape Seed Extract on Lipid Profile and Expression of Interleukin-6 in Polycystic Ovarian Syndrome Wistar Rat Model

Objective Polycystic ovary syndrome (PCOS) is a common but complex endocrine disorder and is the major cause of anovulation and consequent subfertility. In this study effect of GSE on TG, TC, HDL-C, LDL-C and IL-6 in PCOS Wistar rats were assessed. MaterialsAndMethods : In this experimental study, 84 adult female Wistar rats were divided into 7 groups (n=12) including control(intact), Sham(estradiol valerate solvent injection), PCOS and 4 experimental groups. To induce the syndrome, a single subcutaneous injection of 2 mg estradiol valerate was applied. In experimental groups, PCOS rats were treated with different doses of 50, 75, 100 and 200 mg / kg BW GSE by intraperitoneal injection for 10 consecutive days. After harvesting blood serum, TG was measured by GPO-PAP, TC by CHOD-PAP, and HDL-C by sedimentation method, LDL-C by Friedwald calculation and IL-6 by ELISA method.The serum values of each parameter were analyzed using one-way ANOVA at p≤0.05. Results In all experimental groups significant decrease of visceral fat was obvious as compared with PCOS group. LDL-C, TC and IL-6 levels in experimental groups particularly at dose of 50 mg/kg of GSE were significantly decreased as compared with PCOS group. However, HDL-C levels were not significantly changed. Conclusion According to the findings of this study, It can be concluded that GSE with its effects on serum TC, LDL-C and IL-6 could possibly reduce the effects of dyslipidemia and inflammation in PCOS patients and improve systemic symptoms of PCOS.